If you have a PlayStation mouse, use it for this game.
Get a feel for gameplay
Be sure to run through the single-player game first to get a feel for the gameplay. It's hard enough for two or more experienced players to play a multiplayer game, let alone to learn the game.
Don't get distracted
Keep an eye on the furniture and items that you need to protect. Don't get distracted by all the little rats running around, or your game's over.